ZFIN Image: Harris et al., 2019, Figure 6

Image

Figure Caption

Figure 6

Predicted structural differences in the FK1 proline-rich loop. Homology modeling was used to generate predicted models of DrFKBP52 and DrFKBP52-A111V, in the comparison to human FKBP52 and FKBP51 to determine conformational changes induced by the DrFKBP52-A111V mutation. Crystal structures of HsFKBP51 (PDB ID: 1KT0), HsFKBP52 (PDB ID: 1Q1C), DrFKBP52 (predicted), and DrFKBP52-A111V (predicted) are aligned; the respective FK1 domains are shown in space-filled modeling and colored in hydrophobicity scale (blue = hydrophilic, red = hydrophobic). Note that the only differences between FKBP51 and HsFKBP52 within the loop region are at positions 119 and 124.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.