FIGURE

Fig 9

ID

ZDB-FIG-191230-1551

Publication

Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway

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Fig 9

Loss of <italic>jag1b</italic> function decreases the penetrance of <italic>mef2ca</italic>-associated phenotypes.

(A) Animals double heterozygous for mef2ca and jag1b were intercrossed, raised to 6 dpf and fixed and stained with Alcian Blue (cartilage) and Alizarin Red (bone). Genotyped animals were flat mounted and imaged. Removing functional copies of jag1b decreased mef2ca mutant penetrance. Scale bar: 50 μm. (B) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of mef2ca-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with jag1b+/+. (C) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of jag1b-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with mef2ca+/+.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jag1b^b1105/b1105 mef2ca^b1086/b1086 jag1b^b1105/+; mef2ca^b1086/b1086 jag1b^b1105/b1105; mef2ca^b1086/b1086
Observed In:	ceratohyal cartilage ceratohyal-interhyal joint foramen Meckel's cartilage opercle quadrate-anguloarticular joint symplectic
Stage:	Day 6

Phenotype Detail

Acknowledgments

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