FIGURE

Fig 3

ID

ZDB-FIG-191230-1544

Publication

Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway

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Fig 3

Selective breeding just for ectopic bone penetrance modifies penetrance of craniofacial muscle phenotypes.

6 dpf larvae were stained with Alizarin Red (magenta) and fluorescently labelled phalloidin (green) to mark bones and muscles, respectively. (A) The following craniofacial muscles are indicated in the micrograph and graphic: intermandibularis ant. (ima), intermandibularis post. (imp), interhyal (ih), hyohyal (hh), sternohyoideus (sh). Scale bar: 50 μm. (B) In the low-penetrance strain, mef2ca mutant muscles and bones resemble wild types. (C) In the high-penetrance strain, mef2ca mutants manifest muscle phenotypes (asterisks) in conjunction with ectopic bone phenotypes (arrowheads).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mef2ca^b1086/b1086
Observed In:	hyohyoideus interhyoideus intermandibularis
Stage:	Day 6

Phenotype Detail

Acknowledgments

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