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Fig 9

ID: ZDB-IMAGE-191230-1535
Publication: Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway
All Figures: Figures for Sucharov et al., 2019

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Figure Caption

Fig 9 Loss of <italic>jag1b</italic> function decreases the penetrance of <italic>mef2ca</italic>-associated phenotypes.

(A) Animals double heterozygous for mef2ca and jag1b were intercrossed, raised to 6 dpf and fixed and stained with Alcian Blue (cartilage) and Alizarin Red (bone). Genotyped animals were flat mounted and imaged. Removing functional copies of jag1b decreased mef2ca mutant penetrance. Scale bar: 50 μm. (B) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of mef2ca-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with jag1b+/+. (C) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of jag1b-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with mef2ca+/+.

Figure Data

Phenotype details

Acknowledgments

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