Figure 1

The effect of IL‐10‐expressing pDCs on endometriosis development in a surgically induced model. (A) Lesion area and weight from C57BL/6 mice 4 weeks after surgery. The mice were locally treated at the implantation site as indicated. rmIL‐10, recombinant murine IL‐10; IC, isotype control; αmIL‐10, mAb against mouse IL‐10. n = 3 mice in the PBS/rmIL‐10‐treated group; n = 4 mice in the IC/αmIL‐10‐treated group. (B) IL‐10 levels from co‐culture supernatants with or without purified splenic pDCs from C57BL/6 mice (n = 6), apoptotic cells, and R848. Data from two independent experiments are shown. (C) Lesion area and weight from endometrial surgery mice that received PBS or purified splenic pDCs from syngeneic mice intravenously 1 day before surgery. n = 3 mice in the PBS group; n = 4 mice in the pDC group. (D) Lesion area and weight from surgery mice that received PBS or purified splenic pDCs from Il10^−/− and littermate control (Il10^+/+) mice intravenously. n = 3 mice in the PBS and Il10^+/+‐pDC groups; n = 4 mice in the Il10^−/−‐pDC group. The data in A, C, and D represent one of two independent experiments with consistent results. The horizontal line marks the mean for each group. N.D. = not detectable.