FIGURE

Figure 6

ID

ZDB-FIG-190723-1782

Publication

Klüver et al., 2011 - Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression

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Figure 6

Knockdown of Hspb11 results in slow muscle myosin disorganization in skeletal muscles.

(A, D and G) mmMO-hspb11 injected embryos. (B, E and H) MO(ATG)-hspb11 morphants. (C, F and I) MO(UTR)-hspb11 morphants. (A–C) Phenotypic observations of morpholino injected embryos at 48 hpf. (D–E) Muscle organization determined with birefringence at 72 hpf. (G–I) Slow muscle myosin distribution at 72 hpf shown by immunofluorescence staining with antibody F59. Arrows indicate gaps in fiber distribution.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK + MO1-hspb9l + MO5-tp53 WIK + MO2-hspb9l + MO5-tp53
Knockdown Reagents:	MO1-hspb9l MO2-hspb9l MO5-tp53
Observed In:	skeletal muscle slow muscle cell myosin filament
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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