FIGURE

Figure 3

ID

ZDB-FIG-190723-1796

Publication

Klüver et al., 2011 - Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression

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Figure 3

APM mediated <italic>hspb11</italic> induction depends on nAChR activity and increased intracellular calcium levels.

(A) hspb11 expression analysis in ache and sop^fixe−/− zebrafish mutant embryos at 48 hpf. (B) hspb11 expression in sop^fixe null mutants and siblings (+/? = heterozygous and wildtype) after APM (6 µM) exposure (26–50 hpf). (C) 1 µM Thapsigargin (TG) and 2 mM caffeine (CAF) induce hspb11 expression in zebrafish embryos (exposure period 48–50 hpf). Bars represent the relative gene expression as fold change of the respective untreated control as mean ± standard deviation of three independent replicate exposures Control = ctrl. * P<0.05.

Expression Data

Gene:	hspb9l
Fish:	WIK ache^sb55/sb55 chrnd^sb13/sb13
Conditions:	chemical treatment by environment: azinphos-methyl chemical treatment by environment: caffeine chemical treatment by environment: thapsigargin
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK ache^sb55/sb55 chrnd^sb13/sb13
Conditions:	chemical treatment by environment: azinphos-methyl chemical treatment by environment: caffeine chemical treatment by environment: thapsigargin
Observed In:	whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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