FIGURE

Fig. 9

ID

ZDB-FIG-190115-13

Publication

Zhang et al., 2018 - Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function

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Fig. 9

Mitochondrial defects in hair cells. (A) Assessment of mitochondrial function in hair cells by enzyme histochemistry (EHC) staining for SDH and COX in the frozen-sections of posterior macula of mtu1^−/−, mtu1^+/− and mtu1^+/+ zebrafish at 5dpf. Loss of EHC signal is indicated by arrows (magnification X400). V, ventral; L, lateral; Ov, otic vesicle; Hc, hair cell; Sc, supporting cell. (B) Mitochondrial networks from hair cells of inner electron microscopy. Ultrathin sections were visualized with 5000×, 10 000×, 20 000× and 60 000× magnifications. (C) Quantification of mitochondrial numbers of hair cells from the mtu1^−/−, mtu1^+/− mutant and mtu1^+/+ zebrafish. The calculations were based on 50 different hair cells of mtu1^−/−, mtu1^+/− mutant and mtu1^+/+ zebrafish, respectively. Graph details and symbols are explained in the legend to Figure 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	trmu^{zf3047/zf3047}
Observed In:	hair cell posterior macula mitochondrion posterior macula posterior macula cytochrome-c oxidase activity posterior macula succinate dehydrogenase activity
Stage:	Day 5

Phenotype Detail

Acknowledgments

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