FIGURE

Fig. 8

ID

ZDB-FIG-190115-12

Publication

Zhang et al., 2018 - Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function

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Fig. 8

Reduced density of hair cell bundles in inner ear labyrinth. (A) Anatomy of adult wild type zebrafish inner ear labyrinth, showing two lagenas (L), two saccule (S), and two utricle (U). (B–D) Hair bundle density in lagenas, saccule and utricle. The hair cells, nuclei of from mutant and wild type zebrafish were stained with phalloidin (green) and DAPI (blue), respectively. Hair cell counts were sampled at six locations of lagenas, four locations of saccule and six locations of utricle, respectively. A 1600 μm² box was placed at each sampling area and labeled hair cell bundles were counted within each box to determine hair cell density were selected for counting. A, anterior; D, dorsal; M, medial; P, posterior; V, ventral. (E). Quantification of density of hair cell bundles for the mtu1^−/−, mtu1^+/− and mtu1^+/+ zebrafish. Graph details and symbols are explained in the legend to Figure 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	trmu^{zf3047/zf3047}
Observed In:	hair cell macula lagena macula saccule macula utricle
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.