FIGURE

Fig. 3

ID

ZDB-FIG-181207-45

Publication

Liu et al., 2018 - Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish

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Fig. 3

Excessive PKC signaling promotes the degradation of ?-catenin.

a Western blot analysis of ?-catenin. b Quantification of the protein level of ?-catenin relative to wild-type (WT) group (n?=?3 per group, ***p?<?0.001, t-test). c The nuclear accumulation of ?-catenin is reduced by PMA treatment, d indicated by the quantification of ?-catenin⁺/DAPI⁺ dots in brain region (n?=?6 per group, ***p?<?0.001, t-test). e RT-qPCR analysis of the transcriptional target of ?-catenin, mycb, axin2 and jun (n?=?6 per group, *p?<?0.05, t-test)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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