FIGURE

Fig. S1

ID

ZDB-FIG-181022-8

Publication

Lawrence et al., 2018 - The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.

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Fig. S1

col11a2 and col2a1 are largely co-expressed in the zebrafish lower jaw. A-C) Ventral and lateral views of zebrafish at 3dpf. A) In situ hybridisation (ISH) for col11a2 shows its expression in the zebrafish Meckel's cartilage (MC), Palatoquadrate (PQ), ceratohyal (C), and branchial arches (BA) observed ventrally, and the ethmoid plate (EP), otic capsule (OC) and hyosymplectic (HS) laterally. B) The pattern of expression of col11a2 overlaps that of col2a1, visualised with zebrafish carrying Tg(col2a1a:mCherry). White asterisks = joint region. C) immunostaining for Type II collagen (col2) indicates protein deposition in the same domains that col11a2 is expressed, except the jaw joint. Scale bar = 100 µm

Expression Data

Genes:	col11a2 mCherry
Antibody:	Ab1-col2a
Fish:	WT hu5910Tg
Anatomical Terms:	auditory capsule ceratohyal cartilage ethmoid cartilage hyosymplectic cartilage Meckel's cartilage palatoquadrate cartilage pharyngeal arch
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Phil. Trans. Roy. Soc. Lond., Series B