FIGURE

Fig. 6

ID

ZDB-FIG-181022-7

Publication

Lawrence et al., 2018 - The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.

Other Figures

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Fig. 6

Mutations in zebrafish col11a2 result in changes that trigger premature OA. (a,b) Three-dimensional renders from µCTs of 1-year-old wt and col11a2 heterozygous mutant (col11a2+/−). (a) Yellow arrow, jaw joint; dashed green arrow, region of jaw protrusion in col11a2+/−; green arrow, region of hypoplasia in fronto-nasal skeleton. (b) Higher magnification image of joint region where dashed yellow line, inter-joint space. (c,d) Paraffin sections of the jaw joint stained with (c) Alcian blue and haematoxylin/eosin and (d) PicroSirius red. Dashed black line, cartilage layer; black arrows, underlying bone; dashed white line, cartilage; white arrow, bone (green). (e) SHG, asterisks pointing to areas of thinner fibres not detected by SHG, red arrows, thicker collagen bundles on abnormal orientation. Scale bars, 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	col11a2^sa18324/+
Observed In:	mandibular arch skeleton Meckel's cartilage-palatoquadrate cartilage joint Meckel's cartilage-palatoquadrate cartilage joint collagen trimer olfactory region
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Phil. Trans. Roy. Soc. Lond., Series B