FIGURE

Fig. 6

ID

ZDB-FIG-180927-7

Publication

Hu et al., 2018 - Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition

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Fig. 6

Endodermal defects in gpc4 mutants are suppressed by knocking down fn1a and lamb1a. (A-D) Epifluorescence still images of the anterior region of the endodermal sheet in 6s embryos derived from crossing of gpc4/Tg(sox17:EGFP) heterozygous fish injected with or without MOs targeting fn1a and lamb1a (5 ng each). Anterior-dorsal view. White lines of equivalent length indicate width of the anterior endodermal sheets. A, anterior; P, posterior. (E) Average width of anterior endodermal sheet in embryos shown in A-D. Number of embryos analyzed in each group is indicated. *P<0.05, **P<0.01, ****P<0.0001; Student's t-test.

Expression Data

Gene:	EGFP
Fish:	ha01Tg gpc4^fr6/fr6; ha01Tg ha01Tg + MO1-fn1a + MO1-lamb1a + MO4-tp53 gpc4^fr6/fr6; ha01Tg + MO1-fn1a + MO1-lamb1a + MO4-tp53
Knockdown Reagents:	MO1-fn1a MO1-lamb1a MO4-tp53
Anatomical Term:	endodermal cell
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gpc4^fr6/fr6; ha01Tg ha01Tg + MO1-fn1a + MO1-lamb1a + MO4-tp53 gpc4^fr6/fr6; ha01Tg + MO1-fn1a + MO1-lamb1a + MO4-tp53
Knockdown Reagents:	MO1-fn1a MO1-lamb1a MO4-tp53
Observed In:	endoderm
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

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