FIGURE

Fig. S5

ID

ZDB-FIG-180912-60

Publication

Neelathi et al., 2018 - Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.

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Fig. S5

Validation of epcam-MO. (A-C) Injection of 1.2ng epcam morpholino recapitulated a previously published epcam mutant phenotype. It prevented normal morphogenesis of otoliths (shiny crystals lost- arrows). Co-injection of 30ng rescued this morphant phenotype. (D-G) As in the epcam mutants, there was no obvious lateral line phenotype with injection of 1.2ng epcam morpholino. (G) However, when the dose of epcam morpholino was increased to 5 ng, a more variable number of neuromasts was deposited, consistent with previous studies that had suggested that the epcam morpholinos can have some off-target effects. For our study only the low dose of 1.2 ng was used to minimize potential off target effects. Fig.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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