FIGURE

Fig. S5

ID

ZDB-FIG-180911-29

Publication

Guner-Ataman et al., 2018 - Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome

Other Figures

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Fig. S5

Injection of gdf3 mRNA into tbx1 mutants is not sufficient to rescue nkx2.5 expression at 6 somite stage, Related to Figure 5.

(A-F) Brightfield images of 4.7 hours post-fertilization (hpf) (A-C) or 6 somite stage (ss) (D-F) uninjected control (CTRL; A, n=28; D, n=29) and tbx1 mutant (B, n=7; E, n=8) embryos or tbx1 mutant embryos injected with gdf3 mRNA at the one-cell stage (C, n=6; F, n=8). Embryos were processed by in situ hybridization with no tail (A-C) or nkx2.5 riboprobes (D-F). The asterisk in (C) highlights ectopic mesoderm induced by gdf3 mRNA. Lateral views in (A-C). Dorsal views, anterior up in (D-F). Little to no variation was observed between animals in each experimental group. Scale bars=25μm.

Expression Data

Genes:	nkx2.5 tbxta
Fish:	WT tbx1^tu285/tu285
Anatomical Terms:	anterior lateral plate mesoderm margin
Stage Range:	30%-epiboly to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx1^tu285/tu285
Observed In:	anterior lateral plate mesoderm
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

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