FIGURE

Fig. S5

ID

ZDB-FIG-180702-6

Publication

Hocking et al., 2018 - Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye

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Fig. S5

Reduced RA signaling does not impair closure of the superior ocular sulcus.

(A) Lateral view of a 28 hpf zebrafish eye following in situ hybridization for cyp1b1. Note that expression extends into the dorsal eye. (B) Quantification of open SOS in 28 hpf embryos from cyp1b1^+/- incrosses treated from 10 hpf with control solution or the Aldh inhibitor DEAB. N = 3 experiments, n = number of embryos. Data are means ± SEM. Statistics is two-way ANOVA with Tukey's test. Scale bar is 50 ?m. ns, not significant.

Expression Data

Gene:	cyp1b1
Fish:	WT
Anatomical Terms:	eye optic cup dorsal region
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyp1b1^{ua1014/ua1014}
Condition:	chemical treatment by environment: 3-allyl-2-[2-(diethylamino)ethoxy]benzaldehyde
Observed In:	superior ocular sulcus
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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