Gene
cyp1b1
- ID
- ZDB-GENE-030902-1
- Name
- cytochrome P450, family 1, subfamily B, polypeptide 1
- Symbol
- cyp1b1 Nomenclature History
- Previous Names
-
- zgc:136223
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable monooxygenase activity. Acts upstream of or within eye development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyp1b1 | Alexandre-Moreno et al., 2021 | |
| CRISPR2-cyp1b1 | Alexandre-Moreno et al., 2021 | |
| MO1-cyp1b1 | N/A | (3) |
| MO2-cyp1b1 | N/A | Yin et al., 2008 |
| MO3-cyp1b1 | N/A | Williams et al., 2017 |
| TALEN1-cyp1b1 | Hocking et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 6 | Alliance | Anterior segment dysgenesis 6, multiple subtypes | 617315 |
| buphthalmos | Alliance | Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset | 231300 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B8JKD5 | InterPro | 526 | |||||
| UniProtKB:Q1JQ70 | InterPro | 526 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cyp1b1-201
(1)
|
Ensembl | 3,257 nt | ||
| mRNA |
cyp1b1-202
(1)
|
Ensembl | 2,422 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18N13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136223 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194048 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145708 (1) | 3257 nt | ||
| Genomic | GenBank:CT583720 (2) | 215665 nt | ||
| Polypeptide | UniProtKB:B8JKD5 (1) | 526 aa |
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Chen, J., Zhang, M., Zou, H., Aniagu, S., Jiang, Y., Chen, T. (2022) Synergistic protective effects of folic acid and resveratrol against fine particulate matter-induced heart malformations in zebrafish embryos. Ecotoxicology and environmental safety. 241:113825
- Alexandre-Moreno, S., Bonet-Fernández, J.M., Atienzar-Aroca, R., Aroca-Aguilar, J.D., Escribano, J. (2021) Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes. International Journal of Molecular Sciences. 22(12):
- He, L., Chen, Y., Hu, Z., Zhang, Y., Wang, Y., Wei, J., Fan, Z., Xu, J., Peng, M., Zhao, K., Zhang, H., Liu, C. (2021) Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 278:130349
- Huang, Y., Xia, Y., Tao, Y., Jin, H., Ji, C., Aniagu, S., Chen, T., Jiang, Y. (2021) Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Toxicology. 452:152697
- Siddiqui, T., Bhattarai, P., Popova, S., Cosacak, M.I., Sariya, S., Zhang, Y., Mayeux, R., Tosto, G., Kizil, C. (2021) KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease. Cells. 10(10):
- Meng, Q., Yeung, K., Kwok, M.L., Chung, C.T., Hu, X.L., Chan, K.M. (2020) Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones. Environmental pollution (Barking, Essex : 1987). 265:114857
- Ren, F., Huang, Y., Tao, Y., Ji, C., Aniagu, S., Jiang, Y., Chen, T. (2020) Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicology and applied pharmacology. 398:115029
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Boulanger, E., Barst, B.D., Alloy, M.M., Blais, S., Houde, M., Head, J.A. (2019) Assessment of environmentally contaminated sediment using a contact assay with early life stage zebrafish (Danio rerio). The Science of the total environment. 659:950-962
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