ZFIN ID: ZDB-GENE-030902-1
Gene Name: cytochrome P450, family 1, subfamily B, polypeptide 1
Gene Symbol: cyp1b1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:136223

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have monooxygenase activity. Involved in eye development. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
Genome Resources: Alliance (1),  Gene:100150054 (1),  Ensembl(GRCz11):ENSDARG00000068934 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2716 Point Mutation Unknown Premature Stop ENU
ua1014 Small Deletion Unknown Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cyp1b1 N/A 3
MO2-cyp1b1 N/A 1
MO3-cyp1b1 N/A 1
TALEN1-cyp1b1 1
DISEASE ASSOCIATED WITH cyp1b1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 6 Alliance Anterior segment dysgenesis 6, multiple subtypes 617315
buphthalmos Alliance Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset 231300
DISEASE ASSOCIATED WITH cyp1b1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process eye development (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function aromatase activity (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript cyp1b1-201 (1)    Ensembl 3257
mRNA cyp1b1-202 (1)    Ensembl 2422
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyp1b1 No data available
MARKER RELATIONSHIPS
cyp1b1 Contained in: [BAC] DKEY-18N13 (1) (order this)
cyp1b1 Encodes: [cDNA] MGC:136223 (1), MGC:194048 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045256 (1) 2379 nt
Genomic GenBank:CT583720 (1) 215665 nt Blast at MegaBLAST
Polypeptide UniProtKB:B8JKD5 (1) 526 aa
Sequence Information (all 24)
ORTHOLOGY for cyp1b1 ( Chr: 13 )
CITATIONS (107)