| ZFIN ID: ZDB-GENE-030902-1 |
| Gene Name: | cytochrome P450, family 1, subfamily B, polypeptide 1 | |||||||||||||
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| Gene Symbol: | cyp1b1 Nomenclature History |
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Attributions
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| Previous Name: | zgc:136223 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 13 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have monooxygenase activity. Involved in eye development. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:100150054 (1), Ensembl(GRCz11):ENSDARG00000068934 (1) | |||||||||||||
| All Expression Data: | 28 figures from 13 publications |
| Wild-type Stages, Structures: | Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult) |
| High Throughput Expression: | GEO (1) Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa2716 | Point Mutation | Unknown | Premature Stop | ENU | |
| ua1014 | Small Deletion | Unknown | Premature Stop | TALEN |
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| MO1-cyp1b1 | N/A | 3 |
| MO2-cyp1b1 | N/A | 1 |
| MO3-cyp1b1 | N/A | 1 |
| TALEN1-cyp1b1 | 1 |
PHENOTYPE
| Data: | 3 figures from Williams et al., 2017 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 6 | Alliance | Anterior segment dysgenesis 6, multiple subtypes | 617315 |
| buphthalmos | Alliance | Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset | 231300 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | eye development (more) |
| Cellular Component | endoplasmic reticulum (more) |
| Molecular Function | aromatase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| aberrant processed transcript |
cyp1b1-201
(1)
|
3257 |
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|
|
| mRNA |
cyp1b1-202
(1)
|
2422 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM cyp1b1
No data available
MARKER RELATIONSHIPS
| cyp1b1 Contained in: | [BAC] DKEY-18N13 (1) (order this) |
| cyp1b1 Encodes: | [cDNA] MGC:136223 (1), MGC:194048 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001045256 (1) | 2379 nt |
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| Genomic | GenBank:CT583720 (1) | 215665 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:B8JKD5 (1) | 526 aa |
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ORTHOLOGY for cyp1b1 (
Chr:
13
)
CITATIONS (107)