FIGURE

Fig. 3

ID

ZDB-FIG-180628-3

Publication

Kumar et al., 2018 - Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme

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Fig. 3

Phenotypic analysis of pam^−/− zebrafish embryos. Dorsal and lateral views of wildtype (panels A,C,E,G,I,K and M) and pam^mbg5−/− (panels B,D,F,H,J,L and N) embryos; comparison of wildtype (A and C) and pam^mbg5−/− mutants (B and D) revealed no obvious differences at 24 and 48 hpf. By 72 hpf, pam^mbg5−/− embryos develop pericardial edema (asterisk in F); by 96 hpf, additional edema around the abdomen (thin arrows in H and J), irregular cyst-like protrusions in the abdominal region (inset in H), and smaller eyes (arrowheads in H and J) were observed. The general area of the pronephros is indicated by thick arrows (in H and L). Severe edema developed at 5 dpf in pam^mbg5−/− mutants (L and N). Additional edema in the brain was also visible (red arrowhead in L). Developmentally normal wildtype sibling controls at 5 dpf are shown for comparison (K and M). A key to the symbols used is provided.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pam^mbg5/mbg5
Observed In:	brain eye gut heart whole organism
Stage Range:	Long-pec to Days 7-13

Phenotype Detail

Acknowledgments

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