FIGURE

Fig. S6

ID

ZDB-FIG-180628-10

Publication

Kumar et al., 2018 - Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme

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Fig. S6

Undocked centrioles/basal bodies in 6 dpf pam^-/- embryos

Transverse sections through wildtype and pam^-/- embryos (6 dpf). (A, B) Adjacent sections through a cell lining the pronephros of a 6 dpf wildtype embryo showing two basal bodies (BB) with striated rootlets (SR) docked at the plasma membrane with attached membrane-bound ciliary axonemes (cilium) extending into the pronephric lumen; numerous microvilli (MV) are evident. (C, D) Undocked centrioles/basal bodies (arrows) located within the cytoplasm of cells lining the pronephros of a 6 dpf pam^-/- embryo and oriented approximately parallel to the pronephros long axis as are the cytosolic axonemes (see Fig. 5H); few cilia are present in the lumen and microvilli are absent. Bar = 500 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pam^mbg5/mbg5
Observed In:	ciliary basal body-plasma membrane docking pronephros ciliary basal body
Stage:	Day 6

Phenotype Detail

Acknowledgments

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