FIGURE

Fig. S4

ID

ZDB-FIG-180510-40

Publication

Smith et al., 2017 - The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

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Fig. S4

Antisense oligonucleotide mediated depletion of PTP1B enhances cardiomyocyte proliferation. (A) Representative images of cardiomyocyte proliferation 3 days post-amputation (dpa) of the ventricular apex in adult zebrafish treated with a scrambled control morpholino (MO) or a MO directed against PTP1B. Arrows show proliferating cardiomyocytes expressing Mef2 and PCNA. (B) Quantification of proliferating cardiomyocytes 3 dpa expressed as percentage of Mef2+PCNA+ cells relative to cells expressing Mef2 only. Values are means ± S.E. (n=9). *P<0.01 compared to control fish. Adult zebrafish were treated with daily intraperitoneal microinjections of scrambled control or PTP1B MO (1mg/kg) or PTP1B MO with MSI-1436.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med