FIGURE

Fig. 1

ID

ZDB-FIG-180510-42

Publication

Smith et al., 2017 - The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

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Fig. 1

MSI-1436 stimulates adult zebrafish caudal fin regeneration. a Representative images of caudal fin regeneration 4 days post-amputation (dpa) in vehicle- and MSI-1436-treated fish. b Quantification of regenerated caudal fin length 4 dpa. Values are means ± S.E. (n = 12–16). *P < 0.01 compared to vehicle-treated fish. c Representative images of caudal fin blastemas immunostained with antibodies to phosphorylated histone 3 (H3P). Arrows show H3P-positive cells. d Quantification of H3P-positive cells 4 dpa. Values are means ± S.E. (n = 6–8). *P < 0.01 compared to vehicle-treated fish. e Representative images of caudal fin morphology after regeneration is complete at 21 dpa. f Quantification of regenerated caudal fin length 21 dpa. Values are means ± S.E. (n = 10). Fish were given daily given intraperitoneal (IP) injections of either vehicle, 0.125 mg/kg MSI-1436 or 0.125 mg/kg squalamine (squa) following caudal fin amputation. Arrowheads (a, e) show location of amputation plane. Scale bar (a, e) = 1 mm

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med