ZFIN Image: Smith et al., 2017, Fig. S4

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Figure Caption

Fig. S4

Antisense oligonucleotide mediated depletion of PTP1B enhances cardiomyocyte proliferation. (A) Representative images of cardiomyocyte proliferation 3 days post-amputation (dpa) of the ventricular apex in adult zebrafish treated with a scrambled control morpholino (MO) or a MO directed against PTP1B. Arrows show proliferating cardiomyocytes expressing Mef2 and PCNA. (B) Quantification of proliferating cardiomyocytes 3 dpa expressed as percentage of Mef2+PCNA+ cells relative to cells expressing Mef2 only. Values are means ± S.E. (n=9). *P<0.01 compared to control fish. Adult zebrafish were treated with daily intraperitoneal microinjections of scrambled control or PTP1B MO (1mg/kg) or PTP1B MO with MSI-1436.

Acknowledgments

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