FIGURE

Fig. 2

ID

ZDB-FIG-180510-43

Publication

Smith et al., 2017 - The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

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Fig. 2

MSI-1436 stimulates adult zebrafish heart regeneration. a Representative images of cardiomyocyte proliferation 3 days post-amputation (dpa) of the ventricular apex in vehicle-treated fish and MSI-1436-treated fish. Arrows show proliferating cardiomyocytes expressing Mef2 and PCNA. b Quantification of proliferating cardiomyocytes 3?dpa expressed as percentage of cells Mef2-positive cells and PCNA-positive cells relative to cells expressing Mef2 only. Values are means?�?S.E. (n?=?10?12). *P?<?0.01 compared to vehicle-treated fish. c Representative images of Tropomyosin expression in regenerating heart tissue 21?dpa. d Quantification of Tropomyosin expression and injury area 21?dpa. Values are means?�?S.E. (n?=?8?10). *P?<?0.01 compared to vehicle-treated fish. e Representative images of Tg(gata4:GFP) expression in regenerating hearts at 21?dpa. f Quantification of Tg(gata4:GFP) expression and the injury area at 21?dpa. Values are means?�?S.E. (n?=?4-6). *P?<?0.05 compared to vehicle-treated fish. Fish were given daily given intraperitoneal (IP) injections of either vehicle, 0.125?mg/kg MSI-1436 or 0.125?mg/kg squalamine (squa) following ventricular resection. Dashed lines show approximate resection plane

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med