FIGURE

Fig. 2

ID

ZDB-FIG-180323-12

Publication

Herbert et al., 2017 - Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.

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Fig. 2

actr10 mutants have fewer myelinated axons in the ventral spinal cord. (A) Myelinated axons in a control larva in a hemisegment of the ventral spinal cord at 5 dpf. (B) Pseudocoloring and higher magnification enhance visualization of control myelinated axons. (C and D) Myelinated axons are similarly shown in a quadrant of the ventral spinal cord in an actr10^nl15/nl15 mutant animal. (E and F) Myelinated axons in a control larva in a quadrant of the ventral spinal cord at 5 dpf. (G and H) Myelinated axons are similarly shown in a quadrant of the ventral spinal cord in an actr10^stl83/stl83 mutant animal at 5 dpf. (I and J) Quantification revealed a significant difference in the number of myelinated axons in a ventral quadrant between control animals (n = 6) and actr10^nl15/nl15 mutants (n = 4; ***P < 0.0006) (I) and between control animals (n = 8) and actr10^stl83/stl83 mutants (n = 5; ****P < 0.0001) (J) at 5 dpf. Unpaired t tests with Welch’s correction were used for statistical analysis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	actr10^nl15/nl15 actr10^stl83/stl83
Observed In:	spinal cord central nervous system myelination
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA