ZFIN ID: ZDB-FIG-180126-13
Facchinello et al., 2017 - Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports   7:9605 Full text @ Sci. Rep.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: Days 14-20
PHENOTYPE:
Fish:
Observed In:
Stage: Days 14-20

Fig. 6

Defects in vascular endothelium and pancreas development of tcf7l2 exI/exI homozygous larvae. (A,B) Analysis of pancreatic islet and blood vessels inside and around the pancreas of tcf7l2 mutants and wild-type sib controls in Tg(fli1a:EGFP/ins:DsRed) background. Representative images were taken at 18 dpf by confocal microscopy at 20x magnification. (C) Graphic presentation of the integrated density of fluorescence in the red and green channel in tcf7l2 exI/exI mutant and wild-type sib controls at 18 dpf. The regions for the analysis of integrated density of fluorescence are indicated by white boxes. Data were obtained using Fiji software. (D) Analysis and graphic presentation of vessels diameter; the mutant is characterized by decreased vessel diameter. Data were obtained from five individuals per genotype. All reference to phenotypes was confirmed by genotyping; *pā€‰<ā€‰0.05.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed tcf7l2zf55/zf55 ; m1018Tg ; y1Tg standard conditions Days 14-20 pancreas IFL
y1Tg ; m1018Tg control Days 14-20 pancreas IFL
EGFP tcf7l2zf55/zf55 ; m1018Tg ; y1Tg standard conditions Days 14-20 vasculature IFL
y1Tg ; m1018Tg control Days 14-20 vasculature IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tcf7l2zf55/zf55 ; m1018Tg ; y1Tg standard conditions Days 14-20 endocrine pancreas capillary decreased amount, abnormal
Days 14-20 endocrine pancreas capillary decreased diameter, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.