ZFIN ID: ZDB-FIG-180126-11
Facchinello et al., 2017 - Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports   7:9605 Full text @ Sci. Rep.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Term:
Stage: Adult
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 4

Morphology of β cells in wt and tcf7l2 exI/+ heterozygous adults. (A,B) Whole gut tissue extracted from 9 month-old wt and tcf7l2 exI/+ fish in Tg(ins:dsRed) background. Dashed circle: primary islet. Arrowheads: secondary islets and individual β cells extending caudally along the intestine. Examples of projection of a confocal stack image (A’,B’) of primary islets and secondary islet (A”,B”). (C) Quantification of β cells in 9 months old fish. Data were obtained from 3 individuals per genotype, repeated in 2 different experiments.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed m1018Tg control Adult primary islet IFL
tcf7l2zf55/+ ; m1018Tg standard conditions Adult primary islet IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tcf7l2zf55/+ ; m1018Tg standard conditions Adult endocrine pancreas decreased size, abnormal
Adult pancreatic B cell decreased amount, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.