ZFIN ID: ZDB-FIG-180126-11
Facchinello et al., 2017 - Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports   7:9605 Full text @ Sci. Rep.
Anatomical Term:
Stage: Adult
Observed In:
Stage: Adult

Fig. 4

Morphology of β cells in wt and tcf7l2 exI/+ heterozygous adults. (A,B) Whole gut tissue extracted from 9 month-old wt and tcf7l2 exI/+ fish in Tg(ins:dsRed) background. Dashed circle: primary islet. Arrowheads: secondary islets and individual β cells extending caudally along the intestine. Examples of projection of a confocal stack image (A’,B’) of primary islets and secondary islet (A”,B”). (C) Quantification of β cells in 9 months old fish. Data were obtained from 3 individuals per genotype, repeated in 2 different experiments.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed m1018Tg control Adult primary islet IFL
tcf7l2zf55/+ ; m1018Tg standard conditions Adult primary islet IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tcf7l2zf55/+ ; m1018Tg standard conditions Adult endocrine pancreas decreased size, abnormal
Adult pancreatic B cell decreased amount, abnormal
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.