|ZFIN ID: ZDB-FIG-180126-11|
Morphology of β cells in wt and tcf7l2 exI/+ heterozygous adults. (A,B) Whole gut tissue extracted from 9 month-old wt and tcf7l2 exI/+ fish in Tg(ins:dsRed) background. Dashed circle: primary islet. Arrowheads: secondary islets and individual β cells extending caudally along the intestine. Examples of projection of a confocal stack image (A’,B’) of primary islets and secondary islet (A”,B”). (C) Quantification of β cells in 9 months old fish. Data were obtained from 3 individuals per genotype, repeated in 2 different experiments.
|tcf7l2zf55/+ ; m1018Tg||standard conditions||Adult||primary islet||IFL|
|tcf7l2zf55/+ ; m1018Tg||standard conditions||Adult||endocrine pancreas decreased size, abnormal|
|Adult||pancreatic B cell decreased amount, abnormal|
|Acknowledgments:||ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.|