FIGURE

Fig. 5

ID
ZDB-FIG-180103-42
Publication
Yan et al., 2017 - RETRACTED: Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish.
Other Figures
All Figure Page
Back to All Figure Page
Fig. 5

Cell apoptosis analysis of krasV12- and Myc-induced carcinogenesis.

7 dpf WT, kras+ or Myc+ larvae were treated with 10 μM SU5402, 10 μM IWR1 or 10 μM cyclopamine in the presence of 10 μg/ml Dox. Apoptosis was analyzed by immunohistochemical staining with digoxigenin-conjugated nucleaotide and incubated with anti-digoxigenin secondary antibody. (AD) Representative liver images of 7 dpf WT larvae. (EH) Representative liver images of 7 dpf kras+ larvae. (IL) Representative liver images of 7 dpf Myc+ larvae. (M) Statistical analysis of numbers of apoptotic cells in the liver of kras + larvae. (N) Statistical analysis of numbers of apoptotic cells in the liver for Myc+ larvae. N = 20 from each groups; statistical significance: *p < 0.05, Scale bar = 20 μm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.