FIGURE

Fig. 4

ID

ZDB-FIG-180103-40

Publication

Yan et al., 2017 - RETRACTED: Chemical inhibition reveals differential requirements of signaling pathways in kras^V12- and Myc-induced liver tumors in transgenic zebrafish.

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Fig. 4

Cell proliferation analysis of kras^V12- and Myc-induced carcinogenesis.

7 dpf wild type (WT), kras+ or Myc+ larvae were treated with 10 μM SU5402, 10 μM IWR1 or 10 μM cyclopamine in the presence of 10 μg/ml Dox. Cell proliferation was analyzed by immunohistochemical staining with PCNA primary antibody. (A–D) Representative liver image of 7 dpf WT larvae. (E–H) Representative liver image of 7 dpf kras+ larvae. (I–L) Representative liver image of 7 dpf Myc+ larvae. (M) Statistical analysis of numbers of proliferating cells in the livers of kras+ larvae. (N) Statistical analysis of numbers of proliferating cells in the livers of Myc+ larvae. N = 20 from each groups; statistical significance: *p < 0.05, Scale bar = 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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