FIGURE

Fig. 3

ID

ZDB-FIG-171206-47

Publication

Chang et al., 2017 - Ftr82 Is Critical for Vascular Patterning during Zebrafish Development

Other Figures

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Fig. 3

Loss of ftr82 showed edema, circulation defect, and absent parachordal chain. (A,B) At 48 hpf, ftr82 morphants showed incomplete ISV ((B), yellow hollow arrows) and absent parachordal chain (PAC) formation ((B), hollow arrowheads) compared to control (A) by using Tg (fli1a:eGFP)^y1 fish; (G) Quantification of PAC formation with normal (arrowheads in (A)), partial growth (arrows in (A)) or absence (hollow arrowhead in (A)); (C–F) At 72 hpf, representative embryos showed loss of ftr82, resulting in an increasing edema in the brain (arrowhead in (E)) and pericardium (arrows in (E,F)) or blood accumulation at CVP (arrow in (D)); (H) Quantification of ftr82 morphants showed ~90% of embryos with circulation defects in the axial vessels and/or ISVs-DLAVs (n = 38 in control and n = 45 in ftr82 MO); and (I) 80% of ftr82 morphants (n = 31) with mild to severe edema and/or blood blockage compared to control (n = 28). The scale bars in (A,B) represent 200 μm and in (C–F) are 500 μm.

Expression Data

Gene:	EGFP
Fish:	y1Tg y1Tg + MO2-ftr82
Knockdown Reagent:	MO2-ftr82
Anatomical Term:	vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg + MO2-ftr82
Knockdown Reagent:	MO2-ftr82
Observed In:	blood blood circulation brain caudal vein plexus intersegmental vessel lymphangioblast cord pericardium
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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