FIGURE

Fig. 1

ID

ZDB-FIG-171108-11

Publication

Cai et al., 2016 - JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development

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Fig. 1

Figure 1. SP600125 reduced the number of FM1−43FX+ cells. (A–C) We treated 3 dpf zebrafish with or without SP600125 for 2 days and subsequently imaged FM1-43FX+ cells (red). Higher magnification of hair cells of the neuromast taken from z-stacks show that (A) hair cells in untreated controls and (B,C) SP600125-treated animals had no observable morphological differences though there were fewer hair cells in the SP600125-treated animals. Nuclei are stained with DAPI and scale bars = 10 μm. (D) The average number of FM1−43FX+ cells per neuromast (NM) in larvae treated with or without SP600125 for 2 days. The first 4 neuromasts along the body, L1–L4, were recorded on one side of each fish. n = 26 neuromasts in control, n = 28 in 5 μM SP600125-treated neuromasts, n = 40 in 10 μM SP600125-treated neuromasts, and n = 28 in 15 μM SP600125-treated neuromasts. One-way ANOVA; FM1−43FX+ cells: F3, 118 = 96.18, p < 0.001. Bars are mean ± SD. ***p < 0.001, highly significant difference when compared to control larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.