FIGURE

Fig. 4

ID

ZDB-FIG-170314-15

Publication

Meda et al., 2016 - Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

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Fig. 4

Activated SCs express Shh and form a specific structure at the tip of the axon. (A) Schematic representation of the intact fin or the fin after amputation. The squares indicate the position of the acquisitions, and the letters refer to the figure panels of this figure. The dorsal part of the caudal fin was denervated (black arrow) or the fin was amputated (blue arrow). (B) Immunofluorescence staining for GFP in shh:GFP fish (white) and axon cytoskeleton (red) in uncut fin. (C, D) Immunofluorescence staining for GFP in shh:GFP fish (green) and for the axon cytoskeleton (red) in control side (-) and denervated part of a nonamputated fin 2 days postdenervation. (E–G) Immunofluorescence staining for GFP in shh:GFP fish (green) and Sox10 (white) in the whole fin at 0.5 hpa. (F, G) Magnification of (E). (H, I) Immunofluorescence staining for GFP in shh:GFP fish (green), axon cytoskeleton (red), and Sox10 (white) in a cryosection of a regenerating fin at 12 hpa. (I) Magnification of (H). Confocal images, 1–3 μM. Dotted line: amputation plane. Dashed line: distal part of the fin. Scale bars = 50 μM in (B–H) and 25 μM in (I). GFP, green fluorescent protein.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxid. Redox Signal.