FIGURE

Fig. 2

ID

ZDB-FIG-170308-3

Publication

Bower et al., 2017 - Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development

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Fig. 2

Vegfd contributes to the development of parachordal lymphatic endothelial cells. (A-C) Confocal images at 54?hpf showing presence (arrows) or absence (asterisks) of PL formation in representative Tg(fli1a:egfp) vegfc^hu5055, vegfd^uq9bh mutant embryos. (D-F) Quantification of PL formation in vegfd^uq9bh mutant embryos in vegfc^hu5055 wild-type (D), heterozygous (E) and mutant (F) backgrounds. There were significantly fewer PLs formed in vegfd^uq9bh homozygous mutant (n=42) and heterozygous (n=112) embryos when compared with vegfd^uq9bh wild-type (n=63) embryos in a vegfc^hu5055 heterozygous background (E). Error bars represent mean±s.e.m.; ***P<0.001 from one-way ANOVA from three independent clutches of embryos.

Expression Data

Gene:	EGFP
Fish:	vegfc^hu5055/+; y1Tg vegfc^hu5055/+; vegfd^uq9bh/+; y1Tg vegfc^hu5055/+; vegfd^uq9bh/uq9bh; y1Tg
Anatomical Terms:	lymphangioblast cord trunk vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vegfc^{hu5055/hu5055}; y1Tg vegfd^uq9bh/uq9bh; y1Tg vegfc^hu5055/+; vegfd^uq9bh/+; y1Tg vegfc^hu5055/+; vegfd^uq9bh/uq9bh; y1Tg vegfc^{hu5055/hu5055}; vegfd^uq9bh/+; y1Tg vegfc^{hu5055/hu5055}; vegfd^uq9bh/uq9bh; y1Tg (all 6)
Observed In:	lymphangioblast cord lymphangioblast cord lymph vessel development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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