ZFIN ID: ZDB-FIG-170301-21
Nam et al., 2017 - Enhanced antidiabetic efficacy and safety of compound K⁄β-cyclodextrin inclusion complex in zebrafish. Journal of ginseng research   41:103-112 Full text @ J Ginseng Res
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Conditions:
Anatomical Term:
Stage: Day 5
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage: Day 5

Fig. 8

The toxicity of compound K (CK) and β-cyclodextrin included in compound K (CD-CK) in enhanced green fluorescent protein (EGFP) expression fused to the mitochondrial localization sequence (MLS) of zebrafish COXVIII (MLS-EGFP) and TUNEL assays of CK- and CD-CK-treated digestive systems in zebrafish larvae. (A) Representative whole zebrafish images. The red dotted line indicates the digestive system. Scale bar = 100 μm. (B) Size of the digestive system analysis. (C) The fluorescence intensity analysis. (D) The white arrow indicates the location of apoptosis in the digestive system. Scale bar = 50 μm. (E) Quantification of TUNEL-positive apoptosis cells. TUNEL, TdT-UTP nick end labeling. ** p < 0.01 compared to the normal (NOR) group. *** p < 0.001. + p < 0.05.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP cms1Tg control Day 5 digestive system IFL
cms1Tg chemical treatment by environment: beta-cyclodextrin, chemical treatment by environment: ginsenoside C-K Day 5 digestive system IFL
cms1Tg chemical treatment by environment: ginsenoside C-K Day 5 digestive system IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: beta-cyclodextrin, chemical treatment by environment: ginsenoside C-K Day 5 digestive system apoptotic process occurrence, ameliorated
WT chemical treatment by environment: ginsenoside C-K Day 5 digestive system apoptotic process increased occurrence, abnormal
cms1Tg chemical treatment by environment: beta-cyclodextrin, chemical treatment by environment: ginsenoside C-K Day 5 digestive system EGFP expression amount, ameliorated
Day 5 digestive system size, ameliorated
cms1Tg chemical treatment by environment: ginsenoside C-K Day 5 digestive system decreased size, abnormal
Day 5 digestive system EGFP expression decreased amount, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Ginseng Res