FIGURE

Fig. S4

ID

ZDB-FIG-170220-18

Publication

Linsley et al., 2017 - Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3

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Fig. S4

DHPR particles and tetrads are reduced in stac3 mutants but Ryr feet are unaffected. (A) Transverse EM section showing the RyR feet (arrows) at triads in a WT muscle fiber (96 hpf). (B and C) Examples of transverse EM sections showing that the distribution of RyR feet (arrows) in stac3^−/− muscles is comparable to that in WT muscles. (D) Histogram showing that the spacing of tetrads was comparable in fibers from WT (n = 39) and stac3^−/− (n = 25). stac3^−/− expressing Stac3^WT (WT rescue, n = 45) and stac3^−/− expressing Stac3^NAM (NAM rescue, n = 44) larvae (ANOVA, P = 0.07). (E) Histogram showing that the spacing of RyR feet was comparable in WT (n = 27) and stac3^−/− (n = 39) fibers (t test, P = 0.11). SEMs are indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA