FIGURE

Fig. 5

ID

ZDB-FIG-160908-17

Publication

Liu et al., 2016 - Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway

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Fig. 5

Thsd7a knockdown resulted in aberrant Notch1b expression pattern. Whole-mount ISH revealed the spatiotemporal expression patterns of notch1b at 48 hpf with either Thsd7a MO1 (a′-c′) or 5msMO1 (a-c). In the control group, notch1b transcripts were detected in the hind brain with a grid-like pattern (a). In comparison, Thsd7a morphants lost the grid-like expression pattern of notch1b (a′), which were indicated by the white arrows. Reduced expression of notch1b in the spinal cord (b′) was observed. In Thsd7a morphants, notch1b ectopic expression was observed throughout the endocardium in the heart tube (c′) indicated by white arrow head

Expression Data

Gene:	notch1b
Fish:	AB AB + MO1-thsd7aa
Knockdown Reagent:	MO1-thsd7aa
Anatomical Terms:	atrioventricular canal heart hindbrain spinal cord
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-thsd7aa
Knockdown Reagent:	MO1-thsd7aa
Observed In:	atrioventricular canal development heart heart looping hindbrain spinal cord
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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