FIGURE

Fig. 8

ID

ZDB-FIG-160826-18

Publication

Ji et al., 2016 - Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

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Fig. 8

Asymmetric expression of elovl6 requires Nodal signaling but does not depend on Pitx2. (A,B) Analysis of asymmetric pitx2c (A) or elovl6 (B) expression (arrows) at the 18 somite stage (ss) in control embryos and embryos treated with SB-505124 to block Nodal signaling. The graphs indicate the percentage of embryos with normal left-sided expression or absent expression. (C) Asymmetric elovl6 expression (arrows) in wild-type and pitx2HD mutant embryos. n=number of embryos analyzed.

Expression Data

Genes:	elovl6 pitx2
Fish:	AB/TU pitx2^sny15/sny15 (AB/TU) pitx2^sny15/+ (AB/TU)
Condition:	chemical treatment by environment: SB 505124
Anatomical Term:	posterior lateral mesoderm left side
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU pitx2^sny15/sny15 (AB/TU) pitx2^sny15/+ (AB/TU)
Condition:	chemical treatment by environment: SB 505124
Observed In:	left/right pattern formation posterior lateral mesoderm
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.