FIGURE

Fig. 3

ID

ZDB-FIG-160708-3

Publication

He et al., 2016 - Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

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Fig. 3

Neuroblastomas arise from sympathetic neuroblast precursors in MYCN transgenic fish with loss of nf1.

H&E staining of sagittal sections through the tumors in the IRG of nf1a+/+;nf1b+/+;MYCN;GFP (A), nf1a+/-;nf1b+/+;MYCN;GFP (B) and nf1a-/-;nf1b+/+;MYCN;GFP (C) fish at the age of 6 weeks. Immunohistochemical analysis of neuroblastoma markers tyrosine hydroxylase (TH, D-F) and Hu (G-I) expression on sagittal sections through tumors in the IRG of nf1a+/+;nf1b+/+;MYCN;GFP (D,G), nf1a+/-;nf1b+/+;MYCN;GFP (E,H) and nf1a-/-;nf1b+/+;MYCN;GFP (F,I) fish at the age of 6 weeks.

Expression Data

Antibodies:	Ab1-elavl Ab2-th
Fish:	zdf16Tg nf1a^p301/+; zdf16Tg nf1a^p301/p301; zdf16Tg
Anatomical Term:	interrenal gland neuroblastoma
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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