FIGURE

Fig. 8

ID

ZDB-FIG-160708-11

Publication

He et al., 2016 - Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

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Fig. 8

The MEK inhibitor trametinib synergizes with isotretinoin in suppressing nf1-deficient neuroblastoma in vivo.

(A) Neuroblastoma growth in nf1a-/-;nf1b+/+;MYCN;GFP fish treated with vehicle control, trametinib, isotretnoin or combinations of trametinib and isotretnoin. Representative fish are shown in (C). (B) Synergistic effects of trametinib and isotretinoin on tumor suppression were analyzed by isobologram analysis.

Expression Data

Gene:	EGFP
Fish:	nf1a^p301/p301; zdf16Tg
Conditions:	chemical treatment: isotretinoin chemical treatment: trametinib chemical treatment: isotretinoin
Anatomical Term:	interrenal gland neuroblastoma
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nf1a^p301/p301; zdf16Tg
Conditions:	chemical treatment: isotretinoin chemical treatment: trametinib chemical treatment: isotretinoin
Observed In:	interrenal gland neuroblastoma
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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