FIGURE
Fig. 8
- ID
- ZDB-FIG-160708-11
- Publication
- He et al., 2016 - Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain
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Fig. 8
The MEK inhibitor trametinib synergizes with isotretinoin in suppressing nf1-deficient neuroblastoma in vivo. (A) Neuroblastoma growth in nf1a-/-;nf1b+/+;MYCN;GFP fish treated with vehicle control, trametinib, isotretnoin or combinations of trametinib and isotretnoin. Representative fish are shown in (C). (B) Synergistic effects of trametinib and isotretinoin on tumor suppression were analyzed by isobologram analysis. |
Expression Data
| Gene: | |
|---|---|
| Fish: | |
| Conditions: | |
| Anatomical Term: | |
| Stage: | Days 30-44 |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Conditions: | |
| Observed In: | |
| Stage: | Days 30-44 |
Phenotype Detail
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