FIGURE

Fig. 4

ID

ZDB-FIG-160701-5

Publication

Richardson et al., 2016 - Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration

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Fig. 4

Trunk Leader and Follower Cells Present Different Division Dynamics L = 12 and F = 36 from 6 embryos, were analyzed Time in minutes and t₀ = first frame with two separated nuclei. Lateral view and anterior to the left. The error bars represent SEM.

(A and B) Selected frames of a dividing follower cell (Movie S7) (B) and its nuclear tracks, arrow points to dividing follower cell from -40 to 0 thereafter to its front daughter. The arrowhead points to a non-dividing neighbor.

(C and D) Selected frames of a dividing leader cell (Movie S7) and (D) its nuclear tracks, the arrow marks dividing leader from -40 to 0 thereafter to its front daughter. The arrowhead marks a non-dividing neighbor.

(E) Average speed ratio (speed at t_n/average speed), error bars represent SEM. 17 dividing and 20 non-dividing cells, from six embryos, were analyzed.

(F) Left, cumulative distance covered by a representative dividing follower and its non-dividing neighbor. The cumulative distance covered by a representative dividing-leader and its non-dividing follower is shown on the right.

(G) Planes of division categorized as parallel (red) or perpendicular (yellow) relative to the direction of migration (arrow) within 45 degrees (gray shade).