FIGURE

Fig. 1

ID

ZDB-FIG-160525-11

Publication

Deshwar et al., 2016 - The Apelin receptor enhances Nodal/TGF? signaling to ensure proper cardiac development

Other Figures

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Fig. 1

aplnra mutant embryos display defects in endoderm and heart formation.

(A) Schematic detailing the aplnra^max and aplnra^ins alleles. TM indicates the transmembrane domain. (B?E) Gross morphology of aplnra^max,aplnra^ins and aplnra^ins; aplnrb^hu4145 mutant embryos compared to WT (wild type) at 48 hpf (hours post-fertilization). (F-I) nkx2.5 expression at the 15 somite stage in WT, aplnrb^hu4145, aplnra^ins, and aplnra^ins; aplnrb^hu4145 mutant embryos. Dorsal view with anterior to the top. (J-L) In situ hybridization showing expression of myl7 at 48 hpf in aplnra^ins and aplnra^ins; aplnrb^hu4145 embryos compared to WT when viewed from the anterior. (M-P) Comparison of sox17 expression at 8 hpf between WT, aplnra^ins, aplnrb^hu4145and aplnra^ins; aplnrb^hu4145 mutant embryos. Dorsal views are shown with a lateral view in inset panels.

Expression Data

Genes:	myl7 nkx2.5 sox17
Fish:	WT aplnrb^{hu4145/hu4145} aplnra^{zm00177433Tg/zm00177433Tg} aplnrb^{hu4145/hu4145}; aplnra^{zm00177433Tg/zm00177433Tg}
Anatomical Terms:	cardiac muscle cell endodermal cell heart primordium
Stage Range:	75%-epiboly to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aplnra^imb1/imb1 aplnrb^{hu4145/hu4145} aplnra^{zm00177433Tg/zm00177433Tg} aplnrb^{hu4145/hu4145}; aplnra^{zm00177433Tg/zm00177433Tg}
Observed In:	cardiac muscle cell endodermal cell heart heart primordium pericardium
Stage Range:	75%-epiboly to Long-pec

Phenotype Detail

Acknowledgments

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