FIGURE

Fig. 1

ID

ZDB-FIG-160525-11

Publication

Deshwar et al., 2016 - The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

aplnra mutant embryos display defects in endoderm and heart formation.

(A) Schematic detailing the aplnra^max and aplnra^ins alleles. TM indicates the transmembrane domain. (B–E) Gross morphology of aplnra^max,aplnra^ins and aplnra^ins; aplnrb^hu4145 mutant embryos compared to WT (wild type) at 48 hpf (hours post-fertilization). (F-I) nkx2.5 expression at the 15 somite stage in WT, aplnrb^hu4145, aplnra^ins, and aplnra^ins; aplnrb^hu4145 mutant embryos. Dorsal view with anterior to the top. (J-L) In situ hybridization showing expression of myl7 at 48 hpf in aplnra^ins and aplnra^ins; aplnrb^hu4145 embryos compared to WT when viewed from the anterior. (M-P) Comparison of sox17 expression at 8 hpf between WT, aplnra^ins, aplnrb^hu4145and aplnra^ins; aplnrb^hu4145 mutant embryos. Dorsal views are shown with a lateral view in inset panels.

Expression Data

Genes:	myl7 nkx2.5 sox17
Fish:	WT aplnrb^{hu4145/hu4145} aplnra^{zm00177433Tg/zm00177433Tg} aplnrb^{hu4145/hu4145}; aplnra^{zm00177433Tg/zm00177433Tg}
Anatomical Terms:	cardiac muscle cell endodermal cell heart primordium
Stage Range:	75%-epiboly to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aplnra^imb1/imb1 aplnrb^{hu4145/hu4145} aplnra^{zm00177433Tg/zm00177433Tg} aplnrb^{hu4145/hu4145}; aplnra^{zm00177433Tg/zm00177433Tg}
Observed In:	cardiac muscle cell endodermal cell heart heart primordium pericardium
Stage Range:	75%-epiboly to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife