FIGURE

Fig. 3

ID

ZDB-FIG-160512-14

Publication

Zhang et al., 2016 - Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration

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Fig. 3

Ganciclovir inhibits MGPC proliferation. (A) Schematic illustration showing the experimental timeline. Retinas of wild-type zebrafish were injured, and all fish received a pulse of BrdU at 45 hpi. Fish then received intravitreous PBS or GCV injection once daily until 4 dpi. Retinas were collected at indicated time points (48, 72, and 96 hpi). (B) Bromodeoxyuridine immunofluorescence showing that GCV inhibits the expansion of MGPCs in the retina. Bromodeoxyuridine signals are shown in green. (C) Quantification of (B). *P < 0.05 compared to PBS-treated control. n = 3 for each group. Scale bars: 100 µm. The asterisks mark the injury site (needle poke).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.