FIGURE

Fig. 2

ID

ZDB-FIG-160412-21

Publication

Baek et al., 2016 - Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish

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Fig. 2

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Fig. 2

The inhibitory effects of omeprazole on melanogenesis in zebrafish. (a), OMP inhibited pigment formation in developing zebrafish larvae. Bar: 625 µm. (b), OMP decreased the pigment area density in zebrafish larvae. (c), The intracellular Tyr activity decreased to 48% compared with that of the untreated zebrafish larvae. (d), OMP decreased the total melanin pigment amount in zebrafish larvae. (d), OMP inhibited the expression of TYP, TRP-1a, TRP-2 and MITFb mRNA levels in a dose-dependent manner as detected by real-time RT-PCR analysis. Fold changes relative to each gene level in the control are presented as mean ± SD. Each value is expressed as the mean ± SD of triplicate determinations. *P < 0.05 and **P < 0.01 versus the control group.

Expression Data

Genes:	mitfb tyr tyrp1a
Fish:	WT
Condition:	chemical treatment by environment: omeprazole
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: omeprazole
Observed In:	pigmentation whole organism
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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