PUBLICATION

Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish

Authors
Baek, S.H., Lee, S.H.
ID
ZDB-PUB-151216-9
Date
2016
Source
Experimental dermatology   25(3): 239-41 (Journal)
Registered Authors
Keywords
antimelanogenic effects, melanogensis-related proteins, microphthalmia-associated transcription factor, omeprazole, zebrafish
MeSH Terms
  • Animals
  • Arbutin/chemistry
  • Cell Line
  • Copper/chemistry
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation, Developmental/drug effects
  • Melanins/biosynthesis*
  • Melanocytes/drug effects*
  • Mice
  • Microphthalmia-Associated Transcription Factor/metabolism
  • Omeprazole/chemistry*
  • Pigmentation/drug effects
  • Proton Pump Inhibitors/chemistry
  • Skin/drug effects*
  • Tyrosine/chemistry
  • Zebrafish
PubMed
26660505 Full text @ Exp. Dermatol.
Abstract
Recently, it was demonstrated that OMP significantly exhibited antimelanogenic activity via the ATP7A-dependent transport of copper to tyrosinase (9). However, OMP’s inhibitory effect on melanin biosynthesis via MAPKs has not yet been examined. In this study, we investigated whether the effect of MAPK signalling on zebrafish melanin formation is regulated by OMP.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping