PUBLICATION
Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish
- Authors
- Baek, S.H., Lee, S.H.
- ID
- ZDB-PUB-151216-9
- Date
- 2016
- Source
- Experimental dermatology 25(3): 239-41 (Journal)
- Registered Authors
- Keywords
- antimelanogenic effects, melanogensis-related proteins, microphthalmia-associated transcription factor, omeprazole, zebrafish
- MeSH Terms
-
- Animals
- Arbutin/chemistry
- Cell Line
- Copper/chemistry
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Developmental/drug effects
- Melanins/biosynthesis*
- Melanocytes/drug effects*
- Mice
- Microphthalmia-Associated Transcription Factor/metabolism
- Omeprazole/chemistry*
- Pigmentation/drug effects
- Proton Pump Inhibitors/chemistry
- Skin/drug effects*
- Tyrosine/chemistry
- Zebrafish
- PubMed
- 26660505 Full text @ Exp. Dermatol.
Citation
Baek, S.H., Lee, S.H. (2016) Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish. Experimental dermatology. 25(3):239-41.
Abstract
Recently, it was demonstrated that OMP significantly exhibited
antimelanogenic activity via the ATP7A-dependent transport of
copper to tyrosinase (9). However, OMP’s inhibitory effect on
melanin biosynthesis via MAPKs has not yet been examined. In
this study, we investigated whether the effect of MAPK signalling
on zebrafish melanin formation is regulated by OMP.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping