FIGURE

Fig. 3

ID

ZDB-FIG-160406-1

Publication

Roxo-Rosa et al., 2015 - The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR

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Fig. 3

KV-lining cells. (A) Number of cells counted in the whole KV live-microscopy scans of 10–11s.s. WT (n=14) and pkd2-morphant (n=10) embryos. (B) Number of cilia counted in WT (n=6) and pkd2-morphant (n=6) embryos immunodetected for acetylated α-tubulin. (C) Cellular length, width and height of WT (n=6) and pkd2-morphant (n=11) embryos immunodetected for actin cytoskeleton. The box plot and the respective max and min values are indicated. *P<0.01 and **P<0.0001, significantly different from WT. (D) Estimated apical surface area of KV-lining cells. (E) Schematic representation of cell shape of WT and pkd2-morphant KVs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vu119Tg + MO3-pkd2 + MO9-pkd2
Condition:	chemical treatment: forskolin
Knockdown Reagents:	MO3-pkd2 MO9-pkd2
Observed In:	Kupffer's vesicle Kupffer's vesicle apical part of cell Kupffer's vesicle epithelial cell Kupffer's vesicle motile cilium Kupffer's vesicle development
Stage:	10-13 somites

Phenotype Detail

Acknowledgments

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