Fig. 6
The effect of HDAC1 knockdown on the expression of fgf3/8/10 in the developing inner ear. Whole-mount in situ hybridizations with fgf3 (a-f), fgf8 (g-l), and fgf10 (m-r) probes in control embryos (a-c,g-i,m-o) and HDAC1 MO-injected embryos (d-f,j-l,p-r) at different developmental stages (as indicated). Black brackets indicate the localization of fgf3-expressing (a-c), fgf8-expressing (g-i), and fgf10-expressing (m-o) cells. Embryos injected with HDAC1 morpholino show reduction in levels of fgf3 (d-f), fgf8 (j-l), and fgf10 (p-r) expression. The otic vesicles are outlined by dashed lines. All images show lateral views with the anterior to the left and the dorsal side up. |