FIGURE

Fig. 4

ID

ZDB-FIG-160315-29

Publication

He et al., 2016 - Histone deacetylase 1 is required for the development of the zebrafish inner ear

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Fig. 4

Hair cells in the inner ear.

HDAC1 morphants exhibited a normal number of hair cells at 26 hpf but showed significantly fewer hair cells at later time points. (a-d) Brn3c:gfp expression in the inner ear of a control MO-injected embryo (ConMO) (a), a mismatch MO-injected control embryo (ConmisMO) (b), an HDAC1 morphant (c), and an HDAC1-MO + HDAC1mRNA co-injected embryo (d) at 26 hpf. (e-l) Brn3c:gfp expression in the utricle and saccule of a control MO-injected embryo (ConMO) (e), a mismatch MO-injected control embryo (ConmisMO) (f), HDAC1 morphants (g-k), and an HDAC1-MO + HDAC1mRNA co-injected embryo (l) at 48 hpf. All images show lateral views with the anterior to the left and the dorsal side to the top. Positions of the utricular (ut) and saccular (sac) maculae are indicated. (m) Quantification of the numbers of hair cells in the inner ear for each experimental condition at the indicated stages. Data are shown as mean ± SEM (n = 25-45). *p < 0.05. Scale bars, 50 µm.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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