Fig. 3
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- ZDB-FIG-151106-3
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- Boije et al., 2015 - The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina
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Intrinsic Impact on Cell Fate (A) Fate distribution of clones generated by Ptf1a, Atoh7, or Vsx1 morphant cells transplanted into WT hosts. indicates significance for the merged p values of one- and two-cell compared with WT, while # denotes significant difference between one- and two-cell clones within a particular morphant. */# p < 0.05, **/## p < 0.01, ***/### p < 0.001. Error bars depict SEM. The figure legend in (A) is also valid for (B). For the number of clones for the different treatments, see Table S1, and for statistical calculations, see Table S3. (B) Average clone sizes generated from single RPCs scored at 24 hpf for the various morphants in WT environment. (C–F) Representative micrographs of clones generated by Atoh7, Ptf1a, or Vsx1 morphant cells in a WT environment, respectively. The red channel is shown individually for the Ptf1a morphant clone in (E) to reveal the fate switch performed by the Ptf1a lineage to PRs, BCs (marked by arrow head) and GCs (marked by hollow arrow head). Arrowhead in (F) indicates a Ptf1a-positive BC. The scale bar in (C) represents 10 µm and is also valid for (D)–(F). See also Figure S4 and Table S2. |
Reprinted from Developmental Cell, 34(5), Boije, H., Rulands, S., Dudczig, S., Simons, B.D., Harris, W.A., The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina, 532-43, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell