FIGURE
Fig. 4
- ID
- ZDB-FIG-150504-10
- Publication
- Pandey et al., 2015 - Cyclosporin A Disrupts Notch Signaling and Vascular Lumen Maintenance
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Fig. 4
Inhibition of cyclophilin A or calcineurin/NFAT destabilizes lumen structure. (A) Freshly laid Fli1-GFP / GATA1-RFP embryos were incubated in 0.1% DMSO, 2µM FK506, or 40µM N-MeVal-4-CsA (CSA-Analog) for two days. Fluorescent imaging was used to monitor overall vascular development (GFP) and blood flow (RFP). Similar to CSA, neither FK506 nor N-MeVal-4-CSA had an impact on gross morphology or overall vascular development however both drugs blocked blood flow. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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