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Fig. 4 Inhibition of cyclophilin A or calcineurin/NFAT destabilizes lumen structure.
(A) Freshly laid Fli1-GFP / GATA1-RFP embryos were incubated in 0.1% DMSO, 2µM FK506, or 40µM N-MeVal-4-CsA (CSA-Analog) for two days. Fluorescent imaging was used to monitor overall vascular development (GFP) and blood flow (RFP). Similar to CSA, neither FK506 nor N-MeVal-4-CSA had an impact on gross morphology or overall vascular development however both drugs blocked blood flow.
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