FIGURE

Fig. 1

ID

ZDB-FIG-150428-1

Publication

Yang et al., 2015 - CNS Myelination Requires Cytoplasmic Dynein Function

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

The vu76 mutation causes defects in pigment deposition and oligodendrocyte development. Images of living wild-type (A) and vu76 mutant (B) larvae at 6 dpf. The mutant has a smaller brain (bracket) and eye (e) than wild-type and lacks a swim bladder (sb). Lateral (C,E) and dorsal (D,F) views of 5 dpf wild-type and vu76 mutant larvae to show pigment patterns. The dark pigment of the mutant is more broadly distributed than that of the wild-type. Low (G,H) and high (I,J) magnification images of Tg(olig2:EGFP) reporter gene expression in wild-type and mutant larvae. Images are focused on the trunk spinal cord (sc, brackets) with dorsal up. In G and H dorsally migrated OPCs appear as green dots (arrows). Fewer dorsal OPCs are apparent in the vu76 mutant larva than in the wild-type larva. At 6 dpf OPC and oligodendrocyte processes form a dense meshwork (I, boxed area magnified as inset). Oligodendrocyte lineage cell processes are evident in the mutant larva, but the density of processes is less than in wild-type (J, boxed area magnified as inset).

Expression Data

Gene:	EGFP
Fish:	vu12Tg dync1h1^vu76/vu76; vu12Tg
Anatomical Terms:	oligodendrocyte oligodendrocyte cell projection
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dync1h1^vu76/vu76 dync1h1^vu76/vu76; vu12Tg
Observed In:	brain eye oligodendrocyte oligodendrocyte cell projection pigmentation spinal cord dorsal region swim bladder
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.